Assay Development and Screening for Discovery of Validated Chemical Hits for Brain Disorders (R01 Clinical Trial Not Allowed)

The objective of this Notice of Funding Opportunity (NOFO) is to stimulate research in 1) discovery and development of novel, small molecules for their potential use in studying disease treatment relevant to psychiatric disorders; and 2) to generate new insight into the biology of relevant diseases and processes that have yet to be validated as important drug targets. This R01 grant supports fundamental research to develop assays and screen chemical compounds that could lead to new therapeutic approaches for brain disorders and mental health conditions. The program specifically excludes clinical trial activities and focuses on the discovery phase of drug development and target validation.