Catalyze: Product Definition Medical Device Prototype Optimization (R33 - Clinical Trial Not Allowed)

The NHLBI Catalyze Program provides comprehensive support and services to facilitate the transition of basic science discoveries into viable diagnostic and therapeutic candidates cleared for human testing, while developing translational researchers fluent in product development and entrepreneurship. This specific Catalyze Product Definition initiative provides early stage translational support for prototype testing/design modification, assay development for diagnostic disease targets, and development of research tools for use in the treatment of HLBS (Heart, Lung, Blood, and Sleep) diseases and disorders. Following successful completion of the program, potential products will be positioned to move forward for in vivo testing (optimization, safety, efficacy) with additional support from NIH and/or other federal and private programs. This initiative is part of a suite of innovation grants designed to advance projects to meet entry criteria for the NHLBI Catalyze Preclinical Program.