Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular, and circuit substrates of neural function. Studies may be either hypothesis-generating or hypothesis-testing in design and may utilize in vivo, in situ or in vitro experimental paradigms, including model organisms or human cell-based assays. Studies should aim to elucidate the neurobiological impact of individual or combined risk factors, such as the affected molecular and cellular components and their relationships within defined biological processes. The resulting paradigms, component pathways, and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. This R01 activity code is for applications to further develop lines of inquiry where feasibility or proof-of-concept has been established.