Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)

This NIMH funding opportunity supports confirmatory efficacy testing of non-pharmacological therapeutic and preventive interventions for mental disorders in adults and children. As part of NIMH's clinical trials pipeline NOFOs, this announcement addresses unmet therapeutic needs and is consistent with the NIMH emphasis on the experimental therapeutics approach. In this approach, clinical trials should be designed to increase knowledge of the relationship between underlying disease processes and the mechanisms of action through which any intervention produces therapeutic change. This R01 grant requires a clinical trial component and focuses on advancing interventions from earlier stage development to confirmatory efficacy testing.