Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)

The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets. This funding opportunity announcement from the National Institutes of Health supports research that advances understanding of complex human genetic architecture through innovative theoretical and methodological approaches. The program encourages applications that integrate multiple scientific disciplines to address fundamental questions about trait variation at individual, family, and population levels.