Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R01 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) invites research grant applications that propose the development and evaluation of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging in human brain and the incorporation of, pilot or clinical feasibility evaluation from previously collected data in pre-clinical studies. These studies are expected to provide the requisite data needed to advance promising PET ligands for use in clinical research. The program supports the development of innovative imaging biomarkers that can be used for drug discovery and for understanding the pathophysiology of central nervous system (CNS) disorders. Funded projects will contribute to advancing neuroimaging technologies that enable better diagnosis, treatment monitoring, and understanding of brain disorders.