Developmental pathway funding scheme: invited stage two

The Developmental Pathway Funding Scheme (DPFS) provides funding to develop and test novel therapeutics, medical devices, diagnostics and other interventions for healthcare applications. This is the stage two application process, which is by invitation only following a successful stage one application. Projects can cover the full developmental pathway from early development through pre-clinical refinement and testing to early-phase clinical studies and trials (up to phase 2a). The scheme supports academically-led translational projects that aim to improve prevention, diagnosis, prognosis or treatment of significant health needs, or develop research tools that increase the efficiency of developing interventions. All human diseases and medical interventions are eligible, including work on novel therapeutics, vaccines, biologics, advanced therapeutics, medical devices, digital healthcare, diagnostics, medical imaging, surgical techniques, behavioural interventions, and interventions benefiting health in low and middle-income countries. The scheme operates on a milestone-based funding model with go/no-go decision points, typically featuring two to four milestones per award. MRC funds 80% of full economic cost and 100% of permitted exceptions.