Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)

The purpose of this Notice of Funding Opportunity (NOFO) is to further elucidate the mechanisms of early immune development in utero, during the early post-natal period and during early childhood in neonates, infants, and children and adolescents with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART). This initiative aims to understand intricate mechanisms of immune cells at the maternal-fetal interface, T and B cell development and maturation in offspring, and local immune responses and the role of systemic immunity. This R01 grant supports research in pediatric immunology and early human development, focusing on understanding how the immune system develops from prenatal stages through childhood. The program particularly emphasizes research related to HIV exposure and antiretroviral therapy effects on immune development.