Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal of this research is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide key information to facilitate design of durable, broadly protective influenza vaccines. This cooperative agreement supports research into influenza immunity development in infants and children through longitudinal cohort studies.