The role of Food Bioactives on Gut Barrier Function and Healthy Aging

This PhD research opportunity at the University of Leeds invites applications in the field of Food Bioactives and Human Health to investigate the role of food bioactive compounds in modulating gut permeability and their implications for aging and chronic disease. The project is ideal for candidates passionate about nutrition science, molecular biology, and the role of diet in disease prevention and health promotion. The integrity of the gut barrier is increasingly recognized as a key factor in maintaining health and preventing age-related diseases. This project will explore how specific bioactive compounds—such as polyphenols, peptides, and other phytochemicals—affect gut permeability and contribute to systemic inflammation, metabolic dysfunction, and chronic conditions including cardiovascular disease, type 2 diabetes, and neurodegeneration. Research objectives include identification and characterisation of bioactive compounds in selected food sources and by-products rich in target bioactives; in vitro mechanistic research to investigate effects of bioactives on gut epithelial integrity and inflammation; exploration of molecular mechanisms linking gut permeability to inflammation and aging; and design/proof of concept for dietary interventions to improve gut barrier function and support healthy aging. This is not a funded project, but applicants can apply for funding separately. Self-funding students are also welcome to apply. Please note there will be a bench fee of £5,000 per year in addition to the tuition fee for this project.