Wessex One Health BBSRC scholarship: Understanding global control mechanisms for starvation survival in non-tuberculous mycobacteria (NTM)

This project is offered as part of a doctoral programme funded by the Biotechnology and Biological Science Research Council (BBSRC) which will train postgraduate researchers in interdisciplinary approaches to Infection Biosciences across all classes of pathogens, to combat existing and future disease threats to human and animal health, including emerging infections, vector-borne diseases, antimicrobial resistance and food insecurity. The research project aims to elucidate the regulatory mechanisms by which non-tuberculous mycobacteria (NTM) respond to nitrogen starvation, which is especially experienced by cells in deeper layers of biofilms. Non-tuberculous mycobacteria, such as the Mycobacterium avium complex and Mycobacterium abscessus, are opportunistic pathogens that pose significant health risks, particularly to individuals with weakened immune systems. Understanding how biofilm-associated NTM persist in nutrient-poor environments could unlock new strategies to combat their presence in water systems and infections, ultimately helping to reduce the rising incidence of NTM disease. The project will involve a wide variety of molecular biology and microbiological techniques, including the use of biofilm model environments for NTMs. Successful applicants will receive training in a supportive and friendly environment through a partnership between the University of Sussex and the UK Health Security Agency.