Clearing the way: Transforming clot imaging to reveal structural barriers to effective antithrombotic and fibrinolytic therapy

This project will focus on understanding disease mechanisms involved in thrombosis and exploring new targets for the development of new treatments. Thrombosis occurs when abnormal blood clots form inside blood vessels, blocking blood flow to vital organs. The research team has developed a novel method to make whole-blood clots transparent, enabling detailed 3D imaging without damaging the sample. The successful candidate will use and refine this technique to uncover structural determinants of clot stability and breakdown resistance. Experiments will include forming clots under different conditions, imaging their architecture, testing responses to thrombolytic agents, and exploring the role of blood cell composition. The project will also investigate structural changes during thrombus maturation using in-vivo models. This research will provide unprecedented insights into clot formation, growth, and breakdown, informing the development of more effective therapies for treatment-resistant clots. The student will gain expertise in advanced tissue clearing, 3D microscopy, biophysical analysis, and experimental design, as well as training in scientific writing and presentation.