HIV Prevention and Alcohol (R34 Clinical Trials Optional)

This R34 Notice of Funding Opportunity (NOFO) seeks to expand the HIV/AIDS prevention toolkit among alcohol impacted populations with a range of patterns of episodic and long-term use and associated behavioral and biological risks for HIV acquisition. The NOFO supports studies that are both necessary and sufficient to inform the planning of a clinical trial within the scope of the companion announcement HIV Prevention and Alcohol (R01 Clinical Trials Optional). Applications to this NOFO will describe the planned clinical trial and demonstrate that the proposed research is scientifically necessary to design or plan the subsequent trial. This NOFO supports research projects designed to provide results that will be sufficient to inform the future trial without further studies. The planned Phase II, III, or IV trial must be primarily intended to test the efficacy, safety, clinical management, or implementation of intervention(s) in the prevention of HIV. The R34 mechanism is intended to provide new information that answers scientific or operational questions which may be pragmatic in nature, thereby informing the final development of a clinical trial and testing of intervention tools.