Intervertebral Disc Degeneration in Short-legged Dogs – Understanding Chemical and Structural Changes using Computational Methods

This PhD project investigates the fundamental chemical and microstructural changes in intervertebral discs as degeneration progresses in chondrodystrophic dogs (short-legged breeds such as Dachshunds, Welsh Corgis and West Highland Terriers). The project uses molecular dynamic simulations at canine body temperature to understand molecular interactions between the growing mineral phase and native organic molecules (proteoglycans, collagen) in the disc center. The research integrates data from disc material removed during life-saving surgery on canines at The Queen's Veterinary School Hospital, University of Cambridge, to create realistic models. Intervertebral disc herniation (IVDH) in these breeds causes discs to become stiffer, dehydrated and calcified, potentially leading to rupture through the fibrous rim with catastrophic consequences including spinal cord compression, severe pain, and irreversible paralysis. The project aims to use these findings as a starting point for developing new treatments to retard or reverse crystallization of the disc. The work also provides an excellent model for human lumbar disc herniation, with potential translation to improve human treatments and reduce economic productivity loss. The entirely computational project is based at the University of Leeds School of Food Science and Nutrition, with close collaboration with Professor Paul Freeman at the University of Cambridge. Students will have opportunities to visit the Queen's Veterinary School Hospital throughout the project. The position is open to international applicants and requires applicants to contact the supervisor before formal application.