Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)

This funding opportunity from the National Institutes of Health's National Institute of Mental Health (NIMH) supports pilot effectiveness studies as part of NIMH's clinical trials pipeline. The program encourages two main areas of research: 1) optimizing the effectiveness of preventive and therapeutic interventions with previously demonstrated efficacy for use with broader target populations or in community practice settings, and 2) developing and preliminary testing innovative services interventions. Consistent with the NIMH experimental therapeutics approach, this program is intended to support pilot studies of intervention effectiveness or service delivery approaches that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects. This includes examining mechanisms that account for changes in clinical/functional outcomes, changes in provider behavior, improved access or continuity of services, and other relevant factors. The opportunity requires clinical trials and follows NIMH's structured approach to developing and testing mental health interventions.