Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)

This funding opportunity is part of NIMH's clinical trials pipeline and encourages pilot research developing and testing novel psychosocial interventions and/or targets for mental disorders. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. The program provides up to two years of support (R61 phase) for evaluation of target engagement and establishment of intervention parameters, and up to three years of support (R33 phase) to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s). This phased approach allows for iterative refinement of psychosocial interventions based on empirical evidence of target engagement before proceeding to full clinical outcome testing.