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This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions. This R01 grant mechanism is specifically designated as clinical trial not allowed, focusing on fundamental technology development rather than clinical applications.

This Notice of Funding Opportunity (NOFO) supports exploratory research leading to proof of concept for the development of new technologies relevant to the NIGMS mission. Projects should entail a high degree of risk and/or novelty, and have a high future potential impact in biomedical research. The R21 mechanism is designed for early-stage technology development research that establishes the feasibility and proof of concept for innovative biomedical technologies. This funding opportunity encourages high-risk, high-reward projects that have the potential to transform biomedical research capabilities.