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The Investigators in the Pathogenesis of Infectious Disease (PATH) program provides opportunities for assistant professors to bring multidisciplinary approaches to studying human infectious diseases. The program aims to provide accomplished investigators at the assistant professor level with opportunities to study what happens at the points where the systems of humans and potentially infectious agents connect. The program supports research that sheds light on the fundamentals that affect the outcomes of these encounters: how colonization, infection, commensalism, and other relationships play out at levels ranging from molecular interactions to systemic ones. PATH is a highly competitive award program that provides $505,000 over five years to study pathogenesis. The program intends to give recipients the freedom and flexibility to pursue new avenues of inquiry, stimulating higher-risk research projects that hold potential for significantly advancing our understanding of how infectious diseases work and how health is maintained. This career development award requires institutional support and commitment to the applicant's scientific, academic, and personal development.