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The Arc Science Fellows program is designed for outstanding early career scientists who are seeking an opportunity to transition to a principal investigator position directly after their doctoral training. To accelerate independent careers, this program provides Arc Fellows with leadership training and full salary and research support for their group. Arc Science Fellows are active members of the Arc community and have the opportunity to interact and collaborate with Core Investigators, Technology Centers and Translational Programs. Arc Science Fellows are employed by the Institute and appointed for a five-year term at Arc, with a formal check-in after three years. Science Fellows will be independent group leaders that pursue research agendas with a combination of innovative technologies, originality, and risk that are unlikely to be supported by traditional funding sources. Arc Science Fellows are provided an annual direct cost budget to support their research program, including a team of 2-4 people, separate from and in addition to the salary and benefits of the Science Fellow. Fellows labs are located at Arc headquarters in the Stanford Research Park in Palo Alto, CA, a state-of-the-art 100,000 sq. ft. research facility with open lab floor plans that can accommodate up to 5 people per group. The program provides access to robust infrastructure including general operational and lab support, a centralized stockroom, shared equipment for major molecular biology, biochemistry, and genomics workflows, technology platforms and core facilities, and dedicated support teams for recruiting, finance, legal, IP, lab operations, communications, and scientific publication support.