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The Targeted Grants to Institutes program is intended to support established institutes or centers in the mathematics and physical sciences through funding to help strengthen contacts within the international scientific community. The program aims to enable institutes to extend and enhance their missions; this program will not provide primary support for operating or establishing an institute. The funding provided is flexible and based on the type of support requested by the institution in the proposal. Applications may be submitted by established U.S. and foreign public and private educational and nonprofit institutes and research centers. The program is not intended to support institutes or centers whose main purpose is to provide a focal point for research of faculty at a specific university, and will not support national labs or the equivalent with a primary focus on experiments.