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The Adolescent Brain Cognitive Development (ABCD) Study is the largest longitudinal study of brain development and child health collecting data from more than 11,000 children across the U.S. beginning when they are 9-10 years old and continuing for a decade. In addition to behavioral assessments, youth undergo neuroimaging and provide biospecimens, including saliva for hormone analysis, urine and hair for substance use and exposure, deciduous teeth for environmental exposure, and blood for genetic analysis and metabolic and hematologic assays. This initiative allows investigators to apply for access to biological samples from the ABCD Study. The program provides researchers with biospecimens to conduct investigations into brain development, substance use, mental health, environmental exposures, and related health outcomes in adolescents. This is an X01 mechanism that does not allow clinical trials and is specifically designed to facilitate secondary data analysis using existing ABCD Study biospecimens.

The Population Assessment of Tobacco and Health (PATH) Study provides the scientific community with biospecimens (urine, plasma, serum, and genomic DNA) and related research data on behaviors, attitudes, biomarkers and health outcomes associated with tobacco use in the U.S. This opportunity allows investigators to apply for access to the biospecimens from the PATH Study. Information about the PATH Study and this resource may be found on the PATH Study series page at the University of Michigan's National Addiction and HIV Data Archive Program (NAHDAP) website, part of the Inter-University Consortium for Political and Social Research's (ICPSR) website. This is a resource access grant (X01) mechanism through the National Institutes of Health to enable researchers to conduct studies using existing biospecimen data from the PATH Study.